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    B-hCXCR3 mice

    C57BL/6N-Cxcr3tm1(CXCR3)Bcgen/Bcgen • 110969

    B-hCXCR3 mice

    Product nameB-hCXCR3 mice
    Catalog number110969
    Strain nameC57BL/6N-Cxcr3tm1(CXCR3)Bcgen/Bcgen
    Strain backgroundC57BL/6N
    NCBI gene ID2833 (Human)
    AliasesGPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R

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    • Targeting strategy
    • Phenotypic analysis

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      发表文章

        Targeting strategy

        Gene targeting strategy for B-hCXCR3 mice. The full coding region of mouse Cxcr3 was replaced by human CXCR3 coding region sequences in B-hCXCR3 mice.

        Protein expression analysis
        Strain specific CXCR3 expression analysis in homozygous B-hCXCR3 mice by FACS. Splenocytes were collected from wild type (+/+) and homozygous B-hCXCR3 mice (H/H) stimulated with anti-mCD3ε antibody in vivo, and analyzed by FACS with species-specific anti-CXCR3 antibody. Mouse CXCR3 was detectable in wild type mice. Human CXCR3 was exclusively detectable in homozygous B-hCXCR3 mice but not in wild type mice.
        * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-hCXCR3 mice] (Cat# 110969) was purchased from Biocytogen.