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    B-hIFNB1 mice

    C57BL/6N-Ifnb1tm1(IFNB1)/Bcgen • 111210

    B-hIFNB1 mice

    Product nameB-hIFNB1 mice
    Catalog number111210
    Strain nameC57BL/6N-Ifnb1tm1(IFNB1)/Bcgen
    Strain backgroundC57BL/6N
    NCBI gene ID3456 (Human)
    AliasesIFB; IFF; IFNB; IFN-beta

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    • Targeting strategy
    • Phenotypic analysis

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        Targeting strategy

        Gene targeting strategy for B-hIFNB1 mice. The full coding sequence of mouse Ifnb1 was replaced by human IFNB1 coding sequences in B-hIFNB1 mice, so the mouse Ifnb1 gene was disrupted.

        Protein expression analysis
        Strain specific IFNB1 expression analysis in homozygous B-hIFNB1 mice by ELISA. Serum were collected from wild type (+/+) and homozygous B-hIFNB1 mice (H/H) stimulated with LPS for 2 hours in vivo, and analyzed by ELISA with species-specific IFNB1 ELISA kit. Mouse IFNB1 was detectable in wild type mice. Human IFNB1 was exclusively detectable in homozygous B-hIFNB1 mice but not in wild type mice.
        * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-hIFNB1 mice] (Cat# 111210) was purchased from Biocytogen.