C57BL/6-Scarb1tm1(SCARB1)Bcgen/Bcgen • 111115
| Product name | B-hSRB1 mice |
|---|---|
| Catalog number | 111115 |
| Strain name | C57BL/6-Scarb1tm1(SCARB1)Bcgen/Bcgen |
| Strain background | C57BL/6 |
| NCBI gene ID | 949 (Human) |
| Aliases | CLA1; SRB1; CLA-1; SR-BI; CD36L1; HDLCQ6; HDLQTL6 |
Gene targeting strategy for B-hSRB1 mice. The exons 2-11 of mouse Scarb1 gene that encode the extracellular domain and partial transmembrane domain of were replaced by human SCARB1 exons 2-11 in B-hSRB1 mice.
Strain specific analysis of SRB1 gene expression in wild type (WT) mice and B-hSRB1 mice by RT-PCR. Mouse Srb1 mRNA was detectable in liver of WT mice (+/+). Human SRB1 mRNA was exclusively detectable in homozygous B-hSRB1 mice (H/H) but not in WT mice (+/+).
