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      B-Alb-iCreERT2 mice

      C57BL/6-Col1a1tm1(Alb-icre/ERT2)Bcgen/Bcgen • 110137

      B-Alb-iCreERT2 mice

      Product nameB-Alb-iCreERT2 mice
      Catalog number110137
      Strain nameC57BL/6-Col1a1tm1(Alb-icre/ERT2)Bcgen/Bcgen
      Strain backgroundC57BL/6
      NCBI gene ID11657 (Mouse)
      Official symbolAlb, albumin; Alb1; Alb-1; BCL002
      Chromosome11
      AliasesAlb1; Alb-1; BCL001; BCL002; BPL001
      ApplicationB-Alb-iCreERT2 mice expressing icreERT2 under the control of the Alb promoter allow efficient Tamoxifen-dependent recombination of floxed DNA selectively in hepatocytes.

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          Description

          Homozygousmiceforthetargetedmutationareviable,fertile,normalinsizeanddonotdisplayanygrossphysicalorbehavioralabnormalities

          Analysis of liver by immunofluorescence(IF).
          Control: without tamoxifen treatment; HNF4α: a regulator of liver-specific gene expression. Immunofluorescence for HNF4α, tdTomato, and DAPI on liver sections shows Alb-iCreERT2(Mut/+), CAG-LSL-tdTomato(Mut/+) mice labeled almost all hepatocytes after tamoxifen treatment.
          Analysis of kidney by immunofluorescence(IF).

          Control: without tamoxifen treatment; HNF4α: a regulator of liver-specific gene expression. Immunofluorescencefor HNF4α, tdTomato, and DAPI on kidney sections shows Alb-iCreERT2(Mut/+), CAG-LSL-tdTomato(Mut/+) mice were not labeled after tamoxifen treatment.

          * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-Alb-iCreERT2 mice] (Cat# 110137) was purchased from Biocytogen.