C57BL/6N-Ccr2tm1(CCR2)Bcgen/Bcgen • 110097
| Product name | B-hCCR2 mice |
|---|---|
| Catalog number | 110097 |
| Strain name | C57BL/6N-Ccr2tm1(CCR2)Bcgen/Bcgen |
| Strain background | C57BL/6N |
| NCBI gene ID | 729230 (Human) |
| Aliases | CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; PCLUD; CMKBR2; MCP-1-R; CC-CKR-2 |
Gene targeting strategy for B-hCCR2 mice. The exons 3 of mouse Ccr2 gene that encode the full-length protein domain was replaced by human CCR2 exons 2-3 in B-hCCR2 mice.
Strain specific CCR2 expression analysis in homozygous B-hCCR2 mice by flow cytometry. Bone marrow was collected from WT and homozygous B-hCCR2 mice, and analyzed by flow cytometry with species-specific anti-CCR2 antibody. Mouse CCR2 was only detectable in WT mice. Human CCR2 was exclusively detectable in homozygous B-hCCR2 but not WT mice.
