C57BL/6N-Slamf7tm1(SLAMF7)Bcgen/Bcgen • 112530
| Product name | B-hSLAMF7 mice |
|---|---|
| Catalog number | 112530 |
| Strain name | C57BL/6N-Slamf7tm1(SLAMF7)Bcgen/Bcgen |
| Strain background | C57BL/6N |
| NCBI gene ID | 57823 (Human) |
| Aliases | 19A; CS1; CD319; CRACC |
Gene targeting strategy for B-hSLAMF7 mice. The exons 3~5 of mouse Slamf7 gene that encodes the full-length protein was replaced by human SLAMF7 exons 2~4 in B-hSLAMF7 mice.
Strain specific SLAMF7 expression analysis in wild-type C57BL/6 and homozygous B-hSLAMF7 mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 (+/+) and homozygous B-hSLAMF7 mice (H/H) and analyzed by flow cytometry with species-specific anti-SLAMF7 antibody. Mouse SLAMF7 was detectable only in T, B and NK cells in wild-type mice, and hSLAMF7 was exclusively detectable in T, B and NK cells in homozygous mice.
Strain specific SLAMF7 expression analysis in wild-type C57BL/6 and homozygous B-hSLAMF7 mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 (+/+) and homozygous B-hSLAMF7 mice (H/H) and analyzed by flow cytometry with species-specific anti-SLAMF7 antibody. Mouse SLAMF7 was detectable only in monocytes and macrophages in wild-type mice, and hSLAMF7 was exclusively detectable in monocytes and macrophages in homozygous mice.
Strain specific SLAMF7 expression analysis in wild-type C57BL/6 and homozygous B-hSLAMF7 mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 (+/+) and homozygous B-hSLAMF7 mice (H/H) and analyzed by flow cytometry with species-specific anti-SLAMF7 antibody. Mouse SLAMF7 was detectable in T, B, NK cells, monocytes and macrophages in wild-type mice, and hSLAMF7 was exclusively detectable in T, B, NK cells, monocytes and macrophages in homozygous mice.
