德晋贵宾厅

    B-Fabp4-iCre mice

    C57BL/6N-Fabp4tm1(icre)Bcgen/Bcgen • 110152

    B-Fabp4-iCre mice

    Product nameB-Fabp4-iCre mice
    Catalog number110152
    Strain nameC57BL/6N-Fabp4tm1(icre)Bcgen/Bcgen
    Strain backgroundC57BL/6N
    NCBI gene ID11770 (Mouse)
    Official symbolfatty acid binding protein 4
    Chromosome2
    AliasesAp2; P15; ALBP; Lbpl; AFABP; 422/aP2; ALBP/Ap2
    ApplicationB-Fabp4-iCre mice may be useful for Cre-loxP studies of adipocytes.

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    • Description
    • Targeting strategy
    • Phenotypic analysis

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      发表文章

        Description

        Homozygous knockout mice are viable and fertile. Compared to wild-type mice, FABP4-deficient mice exhibit increased susceptibility to diet-induced obesity.

        Gene editing strategy
        Phenotype Analysis
        Scheme for generating RhebADKO mice.The RhebFL/FLmice were crossed with Fabp4-Cremice (Fabp4-Cre micewere purchased from Biocytogen Co.Ltd., Beijing, China) to obtain RhebADKO mice. Rheb was not detected in the interscapular BAT, inguinal and epididymal WAT of RhebADKO mice. Compared to control mice, the interscapular BAT pads of RhebADKO mice were significantly lighter and smaller, while no significant differences were observed in the inguinal and epididymal WAT.
        Instructions of genomic DNA extraction

        chematic representation of the toe clipping.

        * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-Fabp4-iCre mice] (Cat# 110152) was purchased from Biocytogen.